Drug therapy monitoring (TDM) of Digoxin: safety and efficacy review

ABC of monitoring drug therapy. Digoxin.

The plasma digoxin concentration that will result from a given dose of the drug can be predicted at best with only 34% accuracy, although knowledge of a previous concentration improves the ability to predict subsequent concentrations. In outpatients taking a fixed daily dosage, a steady state plasma digoxin concentrations vary widely (between 0 5 and 3 5 nmol/l). This means that if a target pla...

Safety and Efficacy of Digoxin Therapy—Where Are We Now?

The aim of our study was to determine the criteria and key factors for the effectiveness of digoxin therapy. A prospective opened-type study was carried out in conditions of everyday clinical practice. The concentrations of digoxin were quantified from blood samples taken following the achievement of drug steady-state (using AxSYM microparticle enzyme immunoassay-MEIA). The risk/benefit ratio w...

Safety and efficacy of digoxin: systematic review and meta-analysis of observational and controlled trial data

OBJECTIVE To clarify the impact of digoxin on death and clinical outcomes across all observational and randomised controlled trials, accounting for study designs and methods. DATA SOURCES AND STUDY SELECTION Comprehensive literature search of Medline, Embase, the Cochrane Library, reference lists, and ongoing studies according to a prospectively registered design ( PROSPERO CRD42014010783),...

Review: Self monitoring increases the efficacy and safety of anticoagulant therapy.

Therapeutic drug monitoring (TDM) of atazanavir in pregnancy

Methods In this prospective, open labelled study, pregnant HIVpositive women received ATV/r as part of their routine pre-natal care. Demographic and clinical data were collected, and ATV plasma concentrations [ATV] were determined in the first (T1) and/or second (T2) and/or third (T3) trimester using HPLC-MS/MS (LLQ = 0.05 μg/mL). Postpartum (PP) sampling was performed where applicable. Antepar...